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#FreeBSD 11.1 is prone to sendfile related panics, even under moderate load. Had to disable sendfile for nginx and uwsgi for the host serving repology.org after 3 panics in 2 weeks.
Thankfully, it's fixed in 11.2.
@AMDmi3 I never noticed that because I always disable sendfile in nginx because I read somewhere it doesn't interact well with ZFS..