@jennamagius from mosh.org's page it looks like it should be pretty simple to swap out ssh for oxy...
"Mosh doesn't listen on network ports or authenticate users. The mosh client logs in to the server via SSH, and users present the same credentials (e.g., password, public key) as before. Then Mosh runs the mosh-server remotely and connects to it over UDP."
@metagorgon Oxy is rellllatively agnostic of the underlying transport, enabling a pure-UDP no-TCP transport option is a pretty realistic future also.