@miramarco co-operative games work pretty well for this. So things like Pandemic, Forbidden Island/Desert, Eldritch Horror, etc.
Usually each player only plays a single "character" but if it seems a bit slow you can play multiple characters each essentially playing a 3 or 4 person game with two players.
@miramarco @jason_the_concurror confirming, cooperative games work great with only two players. also in that genre, check out Sentinels of the Multiverse. so good.
@jason_the_concurror I was considering co-operative games, but for some reason I didn't think of playing multiple characters at once. Good idea!